Get Design of Regioselective Bilayer Floating Tablets of PDF

By Ajit Kulkarni,Manish Bhatia

examine Paper (postgraduate) from the 12 months 2014 within the topic Pharmicology, grade: 2, , language: English, summary: the aim of the learn was once to layout bilayer floating drugs of Propranolol hydrochloride and Lovastatin to offer quick unencumber of Lovastatin and regulated unlock of Propranolol hydrochloride. Bilayer floating drugs made out of layers, rapid free up layer and regulated unencumber layer. Direct compression approach used to be hired for formula of the bilayer pills. brief time period speeded up balance stories have been conducted at the ready pills. the entire formulations floated for greater than 12h. greater than ninety% Lovastatin was once published inside 30 min. from the formulations. HPMC K4M and Xanthan gum retarded the discharge of Propranolol hydrochloride from the managed liberate layer for 12h. After balance experiences, obvious degradation of either the medication have been came upon however the drug content material used to be discovered to be in the variety. Diffusion exponent (n) was firm for all of the formulations (0.53-7). in keeping with coefficient of correlation(R), the discharge of Propranolol hydrochloride was once came across to keep on with combined unencumber trend of Hixson-Crowell, Korsmeyer-Peppas and matrix, other than formula F6 and F9, which 0 order unlock development. Statistical research printed that there has been no major distinction in in vitro unlock trend of the medication ahead of and after balance studies.

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Design of Regioselective Bilayer Floating Tablets of Propranolol Hydrochloride and Lovastatin for Biphasic Release Profile by Ajit Kulkarni,Manish Bhatia


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